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Friday, July 25, 2014

footDrHorsley provides professional health services for the foot, ankle and related surgeries.

Selected Reading

Osteoarthritis (Degenerative Joint Disease)

Osteoarthritis (OA) is a disease characterized by progressive loss of articular cartilage, appositional new bone formation in the subchondral trabeculae, and formation of new cartilage and new bone at the joint margins. The exact mechanisms by which primary osteoarthritis develops are unknown.

Secondary osteoarthritis is applied to the disease when it appears in response to some local or systemic pathology(disease process).

As far as pathology is concerned, the cartilage appears thicker than normal. An increase in water content leads to swelling of cartilage and an increase in the net rate of proteoglycan (any of a group of glycoproteins (class of protein) present in connective tissue and formed of subunits of disaccharides linked together and joined to a protein core. It serves as a binding or cementing material.) synthesis. The integrity of joint surface is lost and this leads to exposed bone.

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